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LGD 4033 Review
As one of the most popular SARMs on the market today, LGD 4033 has a great reputation in the bodybuilding industry and is considered one of the best supplements for building muscle, it is not classified as a steroid and therefore has no steroid side effects.
With its anti-catabolic effects and powerful anabolic activity, LGD 4033 is ideal for bodybuilders, allowing users to build and cut at the same time. It can be a great addition to your fitness program or layered with other SARMs for better results.
LGD 4033 has a high level of clinical research compared to other SARMs, and while it has not been approved for use in humans and is still being studied, some studies have shown LGD4033 to be beneficial for increasing lean muscle mass, bone density and fat loss.
If you are looking for a product that increases muscle mass, increases stamina and loses fat without the side effects of testosterone. Learn more about LGD 4033 Benefits, LGD 4033 Dosage, LGD 4033 Side Effect & More with LGD 4033 Review.
SARM LGD 4033, also known as Ligandrol, is a non-steroidal oral selective androgen receptor modulator, a compound that targets specific androgen receptors in the body, its primary function is to increase muscle growth and bone density, originally developed with for the treatment of such diseases as muscle wasting and osteoporosis. Due to its bodybuilding benefits, it is one of the most popular SARMs for bodybuilders.
|Other Name：Ligandrol ；LGD-4033|
|Appearance： white powder|
SARM LGD4033 History
LGD-4033 was described in 2007 by the US biotech company Ligand Pharmaceuticals (so LGD4033 is also known as Ligandrol) and is currently being developed by Viking Therapeutics under the code name VK5211, originally developed for the treatment of muscle wasting and osteoporosis Because of its effect on a specific androgen receptor, it can improve the user's muscle mass and bone density, so it is welcomed by the majority of bodybuilders and is widely used in the field of bodybuilding.
Before any drug is put on the market, a lot of clinical research must be carried out. Clinical research includes many stages. Through the research on drug safety, pharmacokinetics and effects, the efficacy and safety of the drug are determined. Since its discovery, LGD4033 has undergone two phases of clinical research.
In a Phase 1 clinical study, investigators focused on the safety, pharmacokinetics and effects of LGD4033 in healthy men
In this study, 76 healthy men (21-50 years old) were randomly assigned to placebo or 0.1, 0.3 or 1.0 mg LGD-4033 daily for 21 days. Blood counts, chemistry, lipids, prostate-specific antigen, electrocardiogram, hormones, lean and fat mass, and muscle strength were measured during and 5 weeks after the intervention.
From this study, the researchers concluded that LGD-4033 is safe, has a favorable pharmacokinetic profile, and increased lean body mass without changes in PSA even during this short period of time.
On November 3, 2015, in a phase 2 clinical study, the researchers tested 120 patients after hip fracture surgery. The subjects were divided into a placebo group and different doses of LGD4033 over a 12-week test period.. By observing the changes of the subjects' net body weight, quality of life, safety and pharmacokinetics.
Through this clinical trial, as a result LGD4033's ability to stimulate and maintain lean body mass, improve muscle strength and improve bone mineral density is beneficial in older adults who are most at risk for and at risk for hip fractures.
As a result, it can be seen that LGD4033 has good effects in terms of safety and pharmacokinetics, can increase and maintain lean body mass, improve muscle strength and improve bone mineral density. This is very beneficial for Bodybuilders in the bodybuilding process.
Clinical studies have shown that the use of LGD4033 can bring various benefits to bodybuilders: muscle mass gain, bone density increase, and fat loss enhancement. Bodybuilders also found that LGD 4033 resulted in fuller muscles and improved results in a shorter period of time than other SARMs.
The main advantages of LGD4033:
1.Rapid muscle growth
2.Powerful fat reduction effect
3.Increased bone density
These advantages of LGD4033 are very beneficial for bodybuilders, let us examine the benefits of LGD4033 in detail below:
Clinical studies have shown that SARMs like LGD 4033 can promote muscle growth. They do this by binding to the body's androgen receptors, mimicking the effects of testosterone, and stimulating muscle tissue to strengthen and swell. LGD-4033 has a half-life of 6 hours, and LGD4033 acts quickly once it enters the body, which is perfect for Bodybuilders who have tried in vain multiple supplements to increase lean muscle mass.
In an ongoing study of LGD4033, researchers are investigating LGD as a treatment for osteoporosis. As we all know, osteoporosis is a problem faced by human beings, which reduces the strength and quality of bones in the human body. Osteoporosis usually has no signs in the early development process, so it is difficult to detect. Osteoporosis is only detected when it causes painful bones, which are already in the later stages.
LGD4033 has shown therapeutic effects on osteoporosis during the research process. One study found that LGD-4033 has a good effect on the bone mineral density of the subjects. For bodybuilders, during the exercise process, it is inevitable to Use heavy weights to improve your workout, which requires good bones to support. Therefore, it is very beneficial for Bodybuilders to increase bone density with LGD4033.
In a study conducted in rats, researchers found that LGD 4033 successfully enhanced male-rat-directed sexual preference in sexually experienced rats, raising awareness that the supplement may also improve in human users of hope.
From this study, the researchers concluded that LGD 4033 may have stimulating effects on certain aspects of female sexuality and may have beneficial effects on female sexual disorders.
From this study, it is envisaged that LGD 4033 could be combined with additional male enhancement supplements for greater effect.
LGD 4033 has anti-catabolic activity, which means it prevents hard-earned muscle breakdown, which is why some users gain lean body mass even in caloric deficits. LGD 4033 indirectly reduces body fat by increasing muscle and skeletal cells, which have a higher metabolic cost to maintain than adipocytes. By increasing muscle mass, an increase in catabolically active metabolism is seen, which leads to easier fat loss.
LGD 4033 can enhance the user's stamina, so bodybuilders show an increase in strength and stamina within a few hours after using LGD 4033, which makes them put more energy into the gym.
A pivotal study measured participants' stair climbing speed and strength as indicators of muscle strength and endurance. Results of the 21-day study showed that participants improved stair climbing speed and strength after using LGD 4033.
Since the half-life of LGD4033 is 24-36 hours, benefits have been documented at doses as low as 3-10 mg every 24 to 36 hours. Study subjects were known to tolerate treatment with significant benefit after 2 weeks, with continued improvement for up to 20 weeks. Note that studies suggest that tolerance increases, and benefits continue to diminish after 3 months.
Many male users report that the ideal upper limit for LGD is 10mg per day in the morning for 12 weeks.
While some women have reported using LGD-4033, it has been suggested that it may cause virilization and a lower dose is recommended. Women are advised to stick to the upper limit of 5mg per day.
The chart below is a simple guide that works for 99.9% of people:
|LGD 4033 Dosage|
|Male||10mg||10mg||8-12 Weeks（with results seen in as little as 4 weeks）|
Bulking Cycle: If you plan to gain weight during this cycle, a protein-rich diet along with a higher calorie intake is also necessary.
Cutting Cycle: During this cycle, you can use stacked SARMs (GW-501516, S-4 and LGD-4033) to reduce fat while increasing size, the recommended dose is 3-5mg per day for 8 weeks.
Recomping Cycle: LGD 4033 is best for recomping. Many users stated that they observed an increase in lean body mass and fat loss.
The compound is non-irritating to the liver and does not cause problems such as high blood pressure, high cholesterol and prostate problems. The recommended dose of LGD 4033 is 10 mg per day for an ideal cycle of 8 to 12 weeks. However, for women, it is recommended to reduce the dose in half.
The half-life of this anabolic compound is 24 to 36 hours, so one dose per day is sufficient. Also, it doesn't matter if you take it with food or on an empty stomach, day or night.
When bodybuilders use testosterone replacement products, testosterone esters, etc., PCT (post-cycle therapy) must perform after a cycle of use.
This is because the body naturally secretes testosterone. If Bodybuilders uses exogenous supplements, the body will think that the testosterone level in the body is sufficient and will actively reduce the natural secretion of testosterone. When exogenous supplementation stops, the body experiences low testosterone levels, leading to a range of low testosterone symptoms.
For bodybuilders, testosterone supplementation can increase muscle mass and strength, which is the original intention of many people to start fitness, so bodybuilders who use testosterone supplements will choose PCT after a normal cycle.
Meanwhile, another group is trying to develop a class of products with less effect on their own testosterone levels, followed by successful development of selective androgen receptor modulators (SARMs).
SARMs have tissue-selective activity. They express anabolism in bone and muscle tissue with high and minimal selectivity in other tissues and organs. The first choice for bodybuilders without causing androgenic side effects like acne and enlarged prostate is SARM.
The tissue-selective activity of SARMs enables some SARMs to completely eliminate PCT, such as SR9009, MK677, and GW501516.
So, does SARMs LGD4033 need PCT?
It depends on the dose.
In 76 adult men receiving escalating doses of LGD4033 0.1mg, 0.3mg and 1mg daily, a dose-dependent increase in muscle mass observes over 21 days. No adverse reactions for more than 21 days. A daily dose of 1 mg of LGD4033 is sufficient to increase lean muscle mass by nearly 3 pounds.
According to the survey, the dosage of bodybuilders is 5mg-10mg per day.
For starters, the initial dose is about 2.5mg per day.
Numerous data indicate that at doses less than 5 mg per day, there are few significant side effects and bodybuilders do not require PCT.
Some bodybuilders may tolerate it well or may choose a higher dose for a given goal. If Bodybuilders use it more than 10 mg per day, between 10-20 mg, need to do a PCT at the end of the cycle
Due to extensive metabolism and prolonged exposure to higher doses, there may be a large number of potential metabolites that are susceptible to haptens and secondary immune responses leading to some hepatotoxicity requiring PCT repair.
Typically, we choose Nolvadex (tamoxifen) for PCT after AAS cycle.
LGD4033 was originally developed to increase anabolism and reduce muscle wasting associated with catabolism and loss of muscle mass. Therefore, LGD4033 is the most suitable SARM for increasing and maintaining muscle mass, usually only in very small amounts.
Side effects can occur with the use of any drug, and both users and researchers of LGD 4033 have noticed some side effects. However, it is worth noting that the side effects of LGD 4033 appear to be not only minimal and reversible, but also have its advantages.
Phase 1 clinical trials showed LGD 4033 was well tolerated and safe at all doses.
However, due to individual differences in users, certain side effects may occur. Some of the side effects reported by users include:
2.hair growth and loss
But it is difficult to say whether these side effects are really attributable to LGD 4033. Various factors can cause these conditions to occur, such as sleep; informal manufacturers produce LGD4033
In these reports, there were no serious or lasting adverse effects from taking LGD 4033.
With its 24-hour half-life, anything you experience will quickly fade away. I also recommend that you limit each cycle to a maximum of 6 to 8 weeks and take a full month off before taking it again.
Most of LGD 4033 powder is white, but the color of some manufacturers may not be white, which is normal. Because the production process of each company will be different, the powder produced will be different.
At present, there are many supplement suppliers selling LGD 4033 on the market, so how can consumers buy high-purity LGD 4033? The best way to do this is to get a sample from the supplement provider first for testing. Detection methods HPLC, HNMR, etc., customers can know the purity and other information of LGD 4033 through detection. Avoid buying low-purity LGD 4033, only buy in bulk after passing the test.
The half-life of LGD is 24-36 hours. When starting to take it, users who have just started to contact LGD4033 may not know when to use LGD4033 to achieve the maximum effect. Due to the long half-life of LGD4033, the use time has little effect on its effect. Some people like to use it before exercise, and some people like to use it after exercise.
In fact, Bodybuilders only needs to use it at set times every day. Bodybuilders can adjust the specific use time according to personal preference.
LGD 4033 is a non-steroidal selective androgen receptor agonist, which has the property of binding to the androgen receptor.
LGD 4033 will affect testosterone secretion to some extent, so bodybuilders use it at reasonable doses and tolerance, it has little effect on Bodybuilders.
Does LGD4033 cause drowsiness?
Long-term use of LGD4033 may indeed cause drowsiness in bodybuilders, because in the process of long-term use, LGD4033 will inevitably suppress the gonads, so it may cause drowsiness in Bodybuilders.
For most Bodybuilders, LGD4033 usually takes about a week of use to start to feel, including strength, pump of training, etc.,
Everyone may be different, usually a week.
As for whether LGD4033 can stack with other SARMs, it depends on the goals of bodybuilders. If bodybuilders want to build muscle, so they can stack with MK677, YK11 and Mk2866. If bodybuilders want to lose fat, so they can stack with GW501516 and MK2866.
LGD4033 does not increase estrogen, it is a SARM, not a steroid. It works differently than steroids, so it does not produce estrogen.
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